Soy Sauce – Gluten Free or Gluten Full?

on Oct16
by Dr. Vikki Petersen | Print the article |

Study Reveals Wheat Containing Soy Sauce ‘Safe’?

This past weekend we hosted our Annual Gluten Sensitivity & Celiac Forum. One of the attendees asked me to address a question regarding soy sauce that he had read on a popular gluten site, Here is my analysis: is an excellent site providing up to date information to those who suffer from gluten intolerance. One of their regular contributing authors, Jefferson Adams, is prolific on the subject and does an outstanding job presenting current research. Last week (October 11, 2012) he posted an article about the proposed safety of soy sauce. He wasn’t discussing the gluten-free tamari that’s available, but rather the standard soy sauce that contains wheat as an ingredient. On the face of it, such a claim might make little sense (considering the wheat on the label), but let’s look at why he proposed that wheat-containing soy sauce might be safe to consume.

I Am Highly Skeptical of this Research

Perhaps I should say, for those who like to skim rather than completely read, I do not agree with the research findings Mr. Adams presented in this case. I do not think that this wheat-containing soy sauce is safe. And for those of you who love to read, last August 8th, I posted a blog titled “Labelled ‘Gluten-free’ but Still Contains Gluten? Yes!” that goes into greater detail of what I am about to discuss.  You can read that blog here.

Okay, now back to the explanation…

Partial Digestion of Gluten is Not Enough to Prevent Problems

Mr. Adams found some research on fermented soy sauces, specifically produced by the companies Kikkoman and Lima foods. Kikkoman uses natural fermentation and Lima foods uses chemical hydrolysis. Hydrolysis is the adding of water in the presence of heat, to break down or predigest a food. Correctly, it was noted that chemical hydrolysis introduces potentially toxic and carcinogenic substances into a food and therefore that soy sauce was not included in the testing he reported. Instead he only reported on the research that utilized soy sauces produced from natural fermentation.

The report stated that the naturally fermented soy sauces tested at under 20 ppm for gluten. In fact it tested under 5 ppm. Those results sound promising, but there’s more to consider.

If such soy sauce is ‘fine’, why then have I found so many patients who go out for sushi or other ethnic food only to have a bad reaction to soy sauce? And since Kikkoman is the brand that seems to have ‘cornered the market’ here in the US, I do feel that I am likely comparing the same soy sauce that the research cited as ‘gluten-free’.

Another Research Team Sheds Light on Hydrolyzed Foods

The answer seems to lie in a different research study published last March inTalanta, a peer-reviewed scientific journal in pure and applied analytical chemistry. In this study the authors focused on hydrolyzed foods and the ‘false negative’ they produced when tested by the standard measuring procedures to determine gluten content in food. The lab report provided by the author on was in another language and therefore difficult to know what method they used, but based upon the fact that they concluded no gluten was present, I presume that they used R5 ELISA, the standard method.

While the Talanta study evaluated beer, baby food and syrup, not soy sauce, I think their findings do lead to some healthy suspicion about soy sauce as well considering that we are discussing hydrolyzed products.

Hydrolysis is a partial digestion or breakdown of food into smaller components – in this case polypeptides. If it was a complete digestion down to individual amino acids, we would certainly have no issues. But it is the ‘partial’ aspect that can be problematic. It is estimated that the overly large gluten protein contains at least 60 fragments that can create negative health effects. Knowing this fact inspired the researchers from the Talanta journal, who hailed from Spain, to come up with a more sensitive (and less expensive) way to measure gluten that had been hydrolyzed.

More Sensitive Testing Shows a lot of Gluten Present!

What they found was that several beers that had gone through the hydrolysis procedure and tested gluten-free according to standard R5 ELISA, in fact were found to have 68 to 218 ppm (parts per million) of gluten when they utilized their more sensitive testing. They call their method ‘sandwich R5 ELISA’.

Did they test soy sauce from Kikkoman? No. But you must admit that the focus here should be less on the exact food than on the fact that a known gluten-containing item underwent hydrolysis and was found to be gluten-free according to standard methods but far from acceptable with a more sensitive method.

When I wrote the blog last August, I stated that most hydrolyzed foods aren’t particularly good for you anyway. I still stand by that, but when you hear ‘natural fermentation‘ (hydrolysis) and a lab report stating that it’s gluten-free, you could easily be compelled to think such a food was safe.

Getting back to our author – Mr. Adams wisely states that you need to make up your own mind and he asks what others have experienced. All I can say is that when I consider the many patients who have reacted negatively to soy sauce and add to that the research from Spain last March, I personally would advise avoiding such food items.

Gluten Affects Many Quite Silently

And finally, remember that gluten can affect the body in many ways that you cannot feel. Stress to your immune system that can create autoimmune disease in several years is not something that you feel at the time. Similarly, nervous system inflammation often occurs for quite a period of time before measureable symptoms manifest. So if you’ve tried this soy sauce and you don’t ‘feel’ bad, realize that isn’t the best benchmark.

If you’re curious, here at HealthNOW’s clinical nutrition department, we can perform a blood test to find out if your immune system is currently reacting to gluten – not something that should be happening if you’re following a strict gluten-free diet.

I hope you found this helpful. Remember that if your health could use some improvement, we are always happy to offer you a free health analysis. Just call us at 408-733-0400. We are here to help!

Our destination clinic sees patients from across the country and internationally, so if you don’t live locally we can still treat you.


“Comprehensive analysis of gluten in processed foods using a new extraction method and a competitive ELISA based on the R5 antibody” Talanta, 91 (March 15, 2012) 33-40, M C Mena, M Lombardia, A Hernando, E Mendez, J P Albar.

To your good health,

Dr Vikki Petersen, DC, CCN
Founder of HealthNOW Medical Center
Co-author of “The Gluten Effect”
Author of the eBook: “Gluten Intolerance – What you don’t know may be killing you!”

The Author

5 Comments, Comment or Ping

  1. 1

    Wow! I love that you addressed my concern so quickly :) I was skeptical of the article on since I had watched your video on gluten free foods that aren’t gluten free. I think it’s sad that potentially dangerous info like this has been published on an authority site like :(

    16 Oct
  2. Sharna Kahn


    You have addressed a very important sub-issue here, Dr. Vicki, and that is… that even though the FDA may eventually define foods to be gluten-free if 20 PPM or below, this piece of legislation does nothing to enforce WHAT tests would be used to determine the gluten levels or HOW the tests would be administered.

    Suffice to say that in regards to any ingredients or claims on labels about the foods we consume, i.e. gluten-free, non GMO, all natural, should be suspicious to the consumer. I’ve learned that our food safety and labeling oversight (audits, some even mandated by federal law) is about the same as airport security…a lot of window dressing for the consumer but not effective and riddled with short cuts and holes.

    16 Oct
  3. Donatella Randazzo


    Soy sauce is full of free glutamate, which derives from the protein fermentation process. The connection between MSG and gluten is quite strong, and this explains why people sensitive to gluten are also very sensitive to MSG (this is my case). I hope that this matter will be further looked into in the future, as I feel it could eventually prove that MSG is bad for the majority of people, even those who do not show any symptoms.

    16 Oct
  4. Sam


    I’ve had celiac for a little over two years. Just tonight I had pad thai, which I was told was gluten free cause it’s made with rice noodles and corn starch. They also told me they don’t put sauce in it but it looked awfully dark and after eating it I tasted soy sauce. Now I’m worried I might get sick. Is there anything I could do to avoid symptoms?

    16 Oct
  5. 5

    Hello Sam,

    I hope you didn’t get ill. I too eat Thai food and here’s what I’ve been told. They more often use fish sauce (also dark in color) than soy, but it depends on the restaurant. If they said they used no soy you’re probably okay.

    If you do worry right after a meal, there is an enzyme that can help somewhat. It’s no “cure” and it is definitely NO license to cheat, but it may provide a bit of relief. It’s called GFCF and you can find it on Amazon.

    Let me know if I can be of further assistance.

    Dr Vikki

    16 Oct

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